College of Science, University of Mustansiriyah discussed a Ph.D. thesis on preparing of new heterocyclic derivatives, their diagnosis and evaluating of their biological effectiveness by the postgraduate student, Mrs. Enas Salem Mahdi.

The thesis aimed preparing new heterocyclic derivatives based on chalcones as raw materials, conducting a biological study to investigate their effectiveness as antioxidants and antimicrobials, and determine the lowest concentration of compounds that can inhibit the MIC, as well as their binding against the galactose enzyme. -Amin_6_Phosphite.

The thesis reviewed preparing of pyrazoline, oxazoline, pyrazoline-1-capothioamide and pyzole derivatives, their diagnosis via using a set of spectroscopic techniques, evaluating of their antimicrobial effectiveness on many types of Gram-positive and gram-negative bacteria (extracted from skin infections and gastrointestinal infections), studying of their antifungal activity and the evaluating of their action as antioxidants, as well as studying the coalescence of active compounds within the binding sites of the enzyme glucosamine-6-phosphate via using (AutoDock 1-4) programs.

The thesis demonstrated the high effectiveness of chalconate, isoxazoline, and pyrrazolene-1-capothioamide derivatives and the possibility of benefiting from them as antimicrobial and antioxidant substances, as these results were strengthened via studying the coalescence of the derivatives.